Bright solitary waves and non-equilibrium dynamics in atomic Bose-Einstein condensates

In this thesis we investigate the static properties and non-equilibrium dynamics of bright solitary waves in atomic Bose-Einstein condensates in the zero-temperature limit, and we investigate the non-equilibrium dynamics of a driven atomic Bose-Einstein condensate at finite temperature. Bright solitary waves in atomic Bose-Einstein condensates are non-dispersive and soliton-like matter-waves which could be used in future atom-interferometry experiments. Using the mean-field, Gross-Pitaevskii description, we propose an experimental scheme to generate pairs of bright solitary waves with controlled velocity and relative phase; this scheme could form an important part of a future atom interferometer, and we demonstrate that it can also be used to test the validity of the mean-field model of bright solitary waves. We also develop a method to quantitatively assess how soliton-like static, three-dimensional bright solitary waves are; this assessment is particularly relevant for the design of future experiments. In reality, the non-zero temperatures and highly non-equilibrium dynamics occurring in a bright solitary wave interferometer are likely to necessitate a theoretical description which explicitly accounts for the non-condensate fraction. We show that a second-order, number-conserving description offers a minimal self-consistent treatment of the relevant condensate -- non-condensate interactions at low temperatures and for moderate non-condensate fractions. We develop a method to obtain a fully-dynamical numerical solution to the integro-differential equations of motion of this description, and solve these equations for a driven, quasi-one-dimensional test system. We show that rapid non-condensate growth predicted by lower-order descriptions, and associated with linear dynamical instabilities, can be damped by the self-consistent treatment of interactions included in the second-order description

Neonatal CD8 T-cell Hierarchy Is Distinct from Adults and Is Influenced by Intrinsic T cell Properties in Respiratory Syncytial Virus Infected Mice

Following respiratory syncytial virus infection of adult CB6F1 hybrid mice, a predictable CD8+ T cell epitope hierarchy is established with a strongly dominant response to a Kd-restricted peptide (SYIGSINNI) from the M2 protein. The response to KdM282-90 is ∼5-fold higher than the response to a subdominant epitope from the M protein (NAITNAKII, DbM187-195). After infection of neonatal mice, a distinctly different epitope hierarchy emerges with codominant responses to KdM282-90 and DbM187-195. Adoptive transfer of naïve CD8+ T cells from adults into congenic neonates prior to infection indicates that intrinsic CD8+ T cell factors contribute to age-related differences in hierarchy. Epitope-specific precursor frequency differs between adults and neonates and influences, but does not predict the hierarchy following infection. Additionally, dominance of KdM282-90 –specific cells does not correlate with TdT activity. Epitope-specific Vβ repertoire usage is more restricted and functional avidity is lower in neonatal mice. The neonatal pattern of codominance changes after infection at 10 days of age, and rapidly shifts to the adult pattern of extreme KdM282- 90 -dominance. Thus, the functional properties of T cells are selectively modified by developmental factors in an epitope-specific and age-dependent manner